MDPHP Orange Glitter: Premium Research Chemical for Advanced Neurochemical Studies

MDPHP Orange Glitter is a high-purity (≥98%) research compound from the pyrovalerone class of synthetic cathinones, meticulously synthesized for advanced scientific investigations . This premium crystalline formulation is specifically designed for researchers conducting neurochemical, pharmacological, and forensic studies requiring precise, consistent materials.

Chemical Identity and Properties

Chemical Name: 3′,4′-Methylenedioxy-α-pyrrolidinohexiophenone
CAS Number: 776994-64-0 (freebase) / 24622-61-5 (hydrochloride) 
Molecular Formula: C₁₇H₂₃NO₃
Molecular Weight: 289.37 g/mol 

MDPHP belongs to the pyrrolidine family of stimulants, structurally related to compounds such as MDPV, α-PHP, and α-PVP . It features a 3,4-methylenedioxy ring substitution with a pyrrolidine moiety and an n-butyl α-alkyl chain (C6), distinguishing it from other members of the homologous series including MDPPP (C3), MDPBP (C4), and MDPV (C5) .

Pharmacological Profile for Research Applications

MDPHP functions as a potent norepinephrine-dopamine reuptake inhibitor (NDRI) with nanomolar affinity at human dopamine and norepinephrine transporters . Research data demonstrate the following transporter inhibition profile:

DAT/SERT Selectivity Ratio: 184 (86–350) 

This selectivity profile makes MDPHP a valuable tool for studying structure-activity relationships (SAR) within the pyrovalerone series. Notably, MDPHP exhibits approximately 24% lower DAT/SERT selectivity compared to MDPV (ratio 241), indicating slightly greater serotonergic engagement—a distinction relevant for understanding the contributions of monoamine transporter balance to cathinone pharmacology .

Research Applications

MDPHP Orange Glitter is suitable for:

• Neurochemical research – Investigating monoamine transporter interactions and neurotransmitter dynamics

• Pharmacological studies – Receptor binding assays and mechanism of action investigations

• Forensic and toxicological analysis – Reference standard for analytical method development 

• Structure-activity relationship studies – Alkyl chain length effects on transporter selectivity and metabolic stability 

• Metabolic research – Studying Phase I and II metabolic pathways and detection windows 

Quality Specifications

• Purity: ≥98% (verified by HPLC, GC-MS, and NMR spectroscopy)

• Physical Form: Orange crystalline solid with distinctive glitter appearance

• Storage: -20°C recommended for long-term stability; ambient shipping conditions

• Solubility: Validated in PBS (10 mg/mL), DMSO (0.5 mg/mL), and Ethanol (1 mg/mL) 

Comparative Research Considerations

Researchers should note that MDPHP produces near-identical locomotor and cardiovascular phenotypes to MDPV at overlapping dose ranges (0.01–20 mg/kg i.p.) in animal models . However, compound-specific metabolic pathways generate structurally divergent metabolites (hydroxylated and glucuronidated derivatives) requiring dedicated analytical standards for accurate forensic quantification .

The extended urinary detection window (>72 hours) compared to MDPV’s acute-phase-only detection supports retrospective toxicological confirmation studies .

Related Research Compounds

For researchers exploring the broader pyrovalerone class, we offer complementary compounds:

• MDPHP Orange Crystal – Alternative crystalline form with comparable purity

• MDPHP Monkey Dust – Fine powder formulation for diverse research applications

Legal and Safety Compliance

MDPHP is regulated as a controlled substance in multiple jurisdictions, including the United States, European Union, and United Kingdom . This product is strictly for legitimate research purposes in authorized laboratory settings. All researchers must comply with applicable local and international controlled substance laws.

Shipping and Handling

RocazoneMix provides secure, discreet worldwide shipping with comprehensive packaging to ensure product integrity. All shipments include proper documentation for research compliance.

This product is intended for research and forensic applications only. Not for human consumption. Verify all applicable regulations before ordering.